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The conservation of gene-function and physiology between people and pigs advocates for the utility of swine for modelling human disease. Furthermore, large litters and advanced reproductive and genome-engineering technologies in swine provide efficient methods for the creation of large-animal models for biomedical and pharmacological research. The release of the Sscr10.2 swine genome build provides a valuable resource for guiding the engineering of the swine genome for the creation of these models.
We have used sequence similarity to identify potential target porcine genes by annotation transfer from the Online Mendelian Inheritance in Man, Human Phenotype Ontology database, Mouse and Rat Genome Databases, as well as the Online Mendelian Inheritance in Animals. This annotation transfer provides an efficient method for understanding current animal models associated with swine/human gene orthologs. The MedSwine portal provides two interfaces for querying these annotations: a GBrowse genome browser and a web search interface that permits searching for genes (by name or ID) or ontology (by ID or term). This resource will facilitate the selection of gene targets and the development of molecular resources for genetic modification by homologous recombination. We demonstrate the utility of this resource by identifying intersections between swine genes, human disease genes, and putative target sites for genome engineering tools. The ability to examine these sites en masse and in the context of gene structure will serve as an invaluable tool for engineering the swine genome for both biomedical and agricultural applications. The MedSwine browser and portal is publicly available at http://vector.cfans.umn.edu/MedSwine/.
We have used sequence similarity to identify potential target porcine genes by annotation transfer from the Online Mendelian Inheritance in Man, Human Phenotype Ontology database, Mouse and Rat Genome Databases, as well as the Online Mendelian Inheritance in Animals. This annotation transfer provides an efficient method for understanding current animal models associated with swine/human gene orthologs. The MedSwine portal provides two interfaces for querying these annotations: a GBrowse genome browser and a web search interface that permits searching for genes (by name or ID) or ontology (by ID or term). This resource will facilitate the selection of gene targets and the development of molecular resources for genetic modification by homologous recombination. We demonstrate the utility of this resource by identifying intersections between swine genes, human disease genes, and putative target sites for genome engineering tools. The ability to examine these sites en masse and in the context of gene structure will serve as an invaluable tool for engineering the swine genome for both biomedical and agricultural applications. The MedSwine browser and portal is publicly available at http://vector.cfans.umn.edu/MedSwine/.