W673 Statistical Issues and the Analysis of Next-Generation Sequencing Data

Date: Sunday, January 15, 2012
Time: 10:20 AM
Room: Pacific Salon 3
Rebecca Doerge , Purdue University, West Lafayette, IN
This is an exciting and influential time for the field of Statistics in science. Technological advances in genetic, genomic, and the other 'omic sciences are providing large amounts of complex data that are presenting a number of challenges for the biological community. Many of these challenges are deeply rooted statistical issues that involve experimental design. Focusing on next-generation sequencing technology, we will introduce the technology and discuss the statistical issues that researchers should be aware of when analyzing these data.  Applications of next-generation sequencing for testing differential expression, as well as investigating the roles of DNA and histone modification, and small RNAs, in heterochromatic silencing and transposon control may be presented.