W409 Stability of plant immune-receptor resistance proteins is controlled by SKP1-CULLIN1-F-box (SCF)-mediated protein degradation

Date: Wednesday, January 18, 2012
Time: 10:20 AM
Room: Pacific Salon 1
Yuti Cheng , University of British Columbia, Vancouver, BC, Canada
Plant Resistance (R) proteins are immune receptors responsible for recognizing pathogen effectors and mounting effective defense responses. Most R proteins contain NB-LRR domains shared by animal innate immunity sensors such as Nod proteins. Heightened levels of R proteins often enhance defense output, while over accumulation of R proteins can trigger autoimmunity. Fine-tuned control of R protein equilibrium is essential for proper pathogen defense. The past decade saw great progress in understanding the regulation of stability of multiple R proteins through SGT1 and SRFR1. However, the exact mechanism of R protein level control is unclear. Here we provide evidence that stability of many R proteins, including SNC1 and RPS2, are directly regulated by SCF-mediated protein degradation.