W199 Using All the Information in the Genome to Coordinate Gene Expression

Date: Saturday, January 14, 2012
Time: 3:50 PM
Room: Pacific Salon 4-5 (2nd Floor)
Richard J. Feldmann , Global Determinants Information Services, Inc., Derwood, MD
Connectrons present a simple sequence-based logic for turning off sets of genes that may be locally grouped on a chromosome or distributed across chromosomes in a variety of ways.  A Connectron is a four-part sequence relationship – two sequences based on the transcription of RNA and two sequences based on DNA.  There are no constraints as to which sequences can form a Connectron.  Connectrons have been found in all three kingdoms in good numbers and in interesting places.  The role of Connectrons in gene expression control in each kingdom is different.  In the last years it has been possible to explain the role of long and short Non-Coding Elements, the Highly Repeated Sequences (HRSs), reverse transcription, the role of Single Nucleotide Polymorphisms (SNPs) and hence the role of Genome Wide Association Studies (GWASs).  The most interesting property of Connectrons – that some transcription has the effect of turning itself off for a period of time while radiating control to many other places – converts the analog character of transcription promotion from Amplitude Modulated (AM) to Frequency Modulated (FM).  In general, FM systems are less noisy than AM systems.

The 11th presentation of this workshop will review the properties of Connectrons and present the computational, graphic and experimental results obtain to date.