Polymorphisms in Positional Candidate Genes on BTA3 and BTA13 Affect Carcass Quality in Hanwoo Cattle

The purpose of this study was to find association between Hamwoo QTL regions andother published data. We identified significant SNPs using Illumina 50k Bovine chip in Hanwooand then compared them in bovine QTL db to investigate candidate genes for the detectedQTL in Hanwoo. Two chromosomes (BTA3 and BTA13) were selected as candidate regionsaccording to the comparison result and we chose those regions which are near to significantSNPs. Consequently, we found some candidate genes in those region and we used the cattlegenome sequences that can serve us much useful information such as QTL, coding regions,transcripts, SNPs, etc. In BTA13, we observed polymorphisms at rs73404(C/T), rs24766(C/T), rs11198(A/G) affecting marbling trait ; at rs324339(A/G), rs26045(G/T) affecting backfattrait and at rs114957(G/T) affecting carcass weight trait(CWT). The candidate genes locatedat 54.5M - 54.6M for carcass weight & backfat trait and at 47M - 48M for marbling trait. InBTA3, we found polymorphisms at rs11769(T/C), rs157501(T/C), rs36465(T/C) affectingLMA ; at rs99764(T/G), rs104552(C/T) affecting marbling trait ; at rs1459226(A/C) affectingcarcass weight trait. The genes that transcripts for, reside at 92.3M for LMA & CWT. So, thesepolymorphisms will help to select Hanwoo cattle having better carcass quality.