The Cacao Genome Database provides a comprehensive data mining resource of genomic and genetic data for the Theobroma cacao cv. Matina 1-6. The database contains the annotated T. cacao cv. Matina1-6 genome, annotated transcript databases, genetic maps and markers, and all publicly available cacao sequences All raw and analyzed data sets of T. cacao cv. Matina 1-6 are available to browse, search and download. The CGD was implemented and designed using Chado and a collection of Drupal modules, known as Tripal. CGD has public and private portals, with all private data password protected. Available visualization and analysis tools include Search, GBrowse, GBrowse-syn, CMap, SSR server, NCBI and Batch BLAST servers. The website is available in English and Portuguese. A breeders toolbox is being developed to provide breeders with access to secure and personalized breeding management databases that directly connect to the public genomic and genetic data relevant for furthering genomics-assisted breeding of cacao. The release of the cacao genome sequence on the CGD will provide researchers with access to the latest genomic tools, enabling more efficient research and accelerating the breeding process, thereby expediting the release of superior cacao cultivars as well as contribute to our basic knowledge of tree biology. CGD can be accessed at http:// www.cacaogenomedb.org.