The UniProt Knowledgebase (UniProtKB): A Richly Annotated Protein Database

Date: Sunday, January 13, 2013
Time: 11:00 AM
Room: California
Wei Mun Chan , EMBL-EBI, Hinxton Cambridge, United Kingdom
The Uniprot Consortium , Protein Information Resource, Washington, DC
The UniProt Knowledgebase (UniProtKB) produced by the UniProt Consortium members, is a central repository collecting functional and sequence information on proteins, and is enriched with accurate, consistent and rich annotations. Ongoing manual and automatic annotation procedures are employed to ensure the information stored in our protein sequence records is kept current and relevant. In addition to the protein sequence each UniProtKB protein sequence record contains additional information including the taxonomy, official gene nomenclature, literature citations, and information pertaining to the protein such as its function, structure, interactions, domains, active sites and post-translational modifications. UniProtKB also provides links to over 150 external databases.

In addition, UniProtKB also currently provides over 3,100 complete proteome sets with each proteome set comprised of both manually and automatically annotated proteins. Each set represents the entries that define the proteome of a specific organism, which are spread over the entire taxonomic range including but not limited to chicken, cow, dog, horse, human, mouse, pig, rat and sheep.

In this presentation the manual and automatic annotation procedures in UniProtKB and the data available in the database will be described.

UniProtKB is available at www.uniprot.org.