Alternative Splicing

Alterative splicing (AS) is an important post-transcriptional process that has a major effect on gene expression. It can create new protein isoforms and regulate gene expression at the post-transcriptional level. Some AS products have phenotypic effects. AS is common in genes of both plants and animals. Next generation sequencing approaches, especially RNA-seq, recently have been used to detect AS events on a genome-wide scale and the number of genes with known AS has increased considerably, up to over 95% in humans. As the number of transcriptome studies using RNA-seq rapidly increases and more genome sequencing projects progress, our knowledge of AS frequency, patterns, and evolutionary conservation will be advanced considerably. Studies are being done to examine the role of abiotic stress conditions on AS and variable AS patterns in different tissue types, as well as to decipher the mechanisms and functional consequences of AS.
Date: Sunday, January 12, 2014
Time: 4:00 PM-6:10 PM
Room: Royal Palm Salon 1-2
Keith Adams
4:00 PM
Evolution of Alternative Splicing Patterns After Whole-genome Duplication
Srikar Chamala, University of Florida; Scott Jackson, University of Georgia; Jeremy Schmutz, Department of Energy Joint Genome Institute; Brad Barbazuk, University of Florida

4:25 PM
Transcriptome-Wide Analysis of Gene Expression and Alternative Splicing in a Splicing Regulator Mutant:  Role of SR45 in Thermotolerance
Anireddy S. Reddy, Colorado State University; Mohammed Albaqami, Colorado State University; Michael Hamilton, Colorado State University; Mark Rogers, Colorado State University; Saiprasad Palusa, Colorado State University; D. Xing, Colorado State University; Gul Shad Ali, Colorado State University; Asa Ben-Hur, Colorado State University

5:15 PM
Analysis of Alternative Splicing Conservation Between Brassica and Arabidopsis
Aude Darracq, University of British Columbia; Keith Adams, University of British Columbia

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