iPTMnet: Integrative Bioinformatics for Knowledge Discovery of PTM Networks

While PTMs play a pivotal role in numerous biological processes by modulating regulation of protein function, critical gaps remain in the current research framework for studying PTMs. To support the studies of important PTMs in plants—phosphorylation, glycosylation, acetylation, myristoylation and ubiquitination—we are integrating text mining, data mining, data analysis and visualization tools, and databases and ontologies into a cross-cutting research resource needed to address the knowledge gaps in exploring and discovering PTM networks. The resource, iPTMnet, is being developed to host a PTM enzyme-substrate database and capture relevant PTM information and their functional impact. A plant-specific use case will be presented.