DM resistance is available in corn germplasm. However, breeding for DM resistant and outstanding corn variety has not been successful through pure conventional means. The use of biotechnology particularly DNA marker has proven efficient to breed for complex trait in major crops including corn e.g. drought tolerance and enhanced protein. We report the successful application of DNA marker technology to breed for DM resistant outstanding yellow corn variety for the Philippines. Corn microsatellite (SSR and EST-SSR) and resistance gene analog (RGA) markers were successfully used to (a) purify parent lines, (b) re-establish genetic structure of recombinant inbred line (RIL) population for genetic mapping, (c) fine-map DM resistance loci (QTL), (d) develop DM resistance gene-specific marker, (e) approximate combining ability based on genetic distance, and (f) in combined marker-assisted selection breeding (MAB) schemes. Resistance QTL were validated in multi-location DM screening involving the major corn growing regions in the Philippines. Multi-location field resistance, resistance under controlled DM-nursery assay and foreground/background DNA markers were the main basis in selecting the final corn lines and test hybrids for yield trial. Best performing DM resistant line/hybrid will be released as a registered new corn variety and/or genetic stock. MAB scheme to introgress DM resistance into the white corn germplasm is proposed; as well as MAB pyramiding with the maize quality protein gene.